Prediction of Function Divergence in Protein Families Using the Substitution Rate Variation Parameter Alpha
نویسندگان
چکیده
منابع مشابه
Prediction of function divergence in protein families using the substitution rate variation parameter alpha.
Protein families typically embody a range of related functions and may thus be decomposed into subfamilies with, for example, distinct substrate specificities. Detection of functionally divergent subfamilies is possible by methods for recognizing branches of adaptive evolution in a gene tree. As the number of genome sequences is growing rapidly, it is highly desirable to automatically detect su...
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15 صفحه اولCorrelation between the substitution rate and rate variation among sites in protein evolution.
It is well known that the rate of amino acid substitution varies among different proteins and among different sites of a protein. It is, however, unclear whether the extent of rate variation among sites of a protein and the mean substitution rate of the protein are correlated. We used two approaches to analyze orthologous protein sequences of 51 nuclear genes of vertebrates and 13 mitochondrial...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2006
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msl002